Aging: ROS or TOR
Volume 7, Issue 21
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November 1, 2008
Pages 3344 - 3354http://dx.doi.org/10.4161/cc.7.21.6965
Authors: Mikhail V. Blagosklonny View affiliations
It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.