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Conceptual Review
Aging: ROS or TOR
Mikhail V. Blagosklonny
Volume 7, Issue 211 November 2008
Pages: 3344 - 3354
This is an open-access article
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It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.
Authors
Mikhail V. Blagosklonny
Ordway Research Institute; Albany, NY
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
