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Perspectives
b-Catenin and Cyclin D1: Connecting Development to Breast Cancer
Tracey M. Rowlands, Irina V. Pechenkina, Sarah Hatsell and Pamela Cowin
volume 3 | issue 2
Feb 2004Pages: 145-148
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b-catenin and cyclin D1 have attracted considerable attention due to their proto-oncogenic roles in human cancer. The finding of cyclin D1 as a direct target gene of b-catenin in colon cancer cells led to the assumption that cyclin D1 upregulation is pivotal to b-catenin's oncogenicity. Our recent paper shows that this is not the case; cyclin D1 dampens the oncogenicity of activated b-catenin (MMTV-DN89b-catenin). The relationships and dependencies of b-catenin and cyclin D1 point to distinct, essential and sequential roles during alveologenisis. These results support the concept that both b-catenin's and cyclin D1's actions are more sophisticated than simple acceleration of the cell cycle clock. These proteins are employed at critical junctures involving cell fate decisions that we speculate require specific types of cel cycle to traverse.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.