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Editor's Corner
Cancer and aging: More puzzles, more promises?
Mikhail V. Blagosklonny and Judith Campisi
Volume 7, Issue 17September 1, 2008
Pages 2615 - 2618
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In this issue of Cell Cycle, a new paper shows that metformin, an oral antidiabetic drug that activates AMP-activated protein kinase, prolongs both mean and maximal life span and prevents reproductive aging of female mice. Unexpectedly, metformin did not decrease the incidence of cancer in this mice strain. Here, we discuss the relationship between aging and cancer, the mechanism of metformin action, and the prospects of using this compound for life span extension in humans.
Authors
- Mikhail V. Blagosklonny
- Ordway Research Institute; Albany, NY
- Judith Campisi
- Lawrence Berkeley National Laboratory; Berkeley, CA
This is an open-access article
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