Sign up for Table of Contents Alerts.

Cell Cycle is published 24 times a year.

Email this page

Print this page

Editor's Corner

Cancer and aging: More puzzles, more promises?

Mikhail V. Blagosklonny and Judith Campisi

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.

In this issue of Cell Cycle, a new paper shows that metformin, an oral antidiabetic drug that activates AMP-activated protein kinase, prolongs both mean and maximal life span and prevents reproductive aging of female mice. Unexpectedly, metformin did not decrease the incidence of cancer in this mice strain. Here, we discuss the relationship between aging and cancer, the mechanism of metformin action, and the prospects of using this compound for life span extension in humans.

Authors

Mikhail V. Blagosklonny

Ordway Research Institute; Albany, NY

Judith Campisi

Lawrence Berkeley National Laboratory; Berkeley, CA

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.