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Mechanisms of microRNA deregulation in human cancer

Shan Deng, George Adrian Calin, Carlo M. Croce, George Coukos and Lin Zhang

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microRNAs (miRNAs) are an abundant class of small non-coding RNAs that function as gene regulators. Although deregulation of miRNA expression is involved in the initiation and progression of tumorigenesis, the underlying mechanisms of miRNA deregulation in human cancer are still largely unknown. Increasing evidence indicates that transcriptional deregulations, epigenetic alterations, mutations, DNA copy number abnormalities and defects in the miRNA biogenesis machinery might contribute to miRNA deregulation in human cancer. A clearer understanding of the mechanisms involved in miRNA deregulation in human cancer will contribute greatly to the development of new miRNA-based strategies in cancer diagnosis and treatment.

Authors

Shan Deng

University of Pennsylvania; Philadelphia, PA

George Adrian Calin

MD Anderson Cancer Center; Houston, TX

Carlo M. Croce

Ohio State University; Columbus, OH

George Coukos

University of Pennsylvania; Philadelphia, PA

Lin Zhang

University of Pennsylvania; Philadelphia, PA

Purchase article for $19

Subscribe to this journal for $129/year