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Perspectives
To Be or Not to Be...Ubiquitinated?
Joanna Bloom and Michele Pagano
volume 3 | issue 2
Feb 2004Pages: 138-140
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Levels of p21, a cyclin-dependent kinase (CDK) inhibitor, are controlled in part at the post-translational level by protein degradation. Although the signaling pathways leading to p21 degradation have not yet been fully elucidated, it is evident that p21 ubiquitination is an essential factor in its degradation. We discuss that, with the only notable exception of ornithine decarboxylase, ubiquitination appears a prerequisite for proteasomal degradation rather than an unnecessary byproduct of such proteolysis.
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.