Sign up for Table of Contents Alerts.

Email this page

Print this page

Reports

The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigen

An Wu, Jia Chen and Renato Baserga

Purchase article for $19

Subscribe to this journal for $129/year

The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other. Tag is a nuclear protein even in the absence of IRS-1, but IRS-1 is required for occupancy and activation by Tag of the ribosomal DNA (rDNA), cyclin D1 and c-myc promoters. Our results indicate that IRS-1 plays a significant role in Tag activation of cell cycle progression genes.

Authors

An Wu

Thomas Jefferson University; Philadelphia, PA

Jia Chen

Thomas Jefferson University; Philadelphia, PA

Renato Baserga

Thomas Jefferson University; Philadelphia, PA

Purchase article for $19

Subscribe to this journal for $129/year