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Perspectives

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

Paolo Pinton and Rosario Rizzuto

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The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its pro-apoptotic activity upon oxidative stress. This model, that could explain the alterations of mitochondrial Ca2+ homeostasis observed after oxidative stress, highlights novel pharmacological targets in age-related disorders.

Authors

Paolo Pinton

University of Ferrara; Ferrara, Italy

Rosario Rizzuto

University of Ferrara; Ferrara, Italy

Purchase article for $19

Subscribe to this journal for $129/year