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Review

Organ size determination and the limits of regulation

Ben Z. Stanger

This is an open-access article

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The size of an organism dictates both its functional challenges and how it meets them. Despite being a universal feature of all living creatures, how an organism determines its size, and that of its internal organs, is largely unknown. In particular, the mechanisms by which organs sense magnitude and alter cellular behavior to ensure symmetry, proportionality, and correct final size are unknown. This review outlines our current understanding of the field and highlights several important outstanding questions.

Authors

Ben Z. Stanger

University of Pennsylvania; Philadelphia, PA

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.