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HDAC6 a new cellular stress surveillance factor

Patrick Matthias, Minoru Yoshida and Saadi Khochbin

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Less than a decade has passed since HDAC6 was first identified and regarded as an unusual histone deacetylase harbouring two catalytic domains. Early demonstration of its cytoplasmic localisation, its ubiquitin-binding and its tubulin-deacetylase activities took HDAC6 far away from everything known to involve other histone-deacetylases. Recent discoveries confirmed the very unique functions of HDAC6 among deacetylases and pointed to this protein as a master regulator of cell response to cytotoxic assaults. HDAC6 appears both as a sensor of stressful stimuli and as an effector, which, thanks to its wide range of activities, mediates and coordinates appropriate cell responses.

Authors

Patrick Matthias

Friedrich Miescher Institute for Biomedical Research; Basel, Switzerland

Minoru Yoshida

RIKEN; Wako, Saitama, Japan

Saadi Khochbin

Universite Joseph Fourier; Grenoble, France

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Subscribe to this journal for $129/year