Sign up for Table of Contents Alerts.

Email this page

Print this page

Perspectives

TNF signaling gets FLIPped off: TNF-induced regulation of FLIP

Stuart A. Rushworth, Alison Taylor, Susana Langa and David J. MacEwan

Purchase article for $19

Subscribe to this journal for $129/year

One of the major guardians of death receptor mediated programmed cell death is FLIP (Fas-associated protein with death domain-like IL-1β-converting enzyme (FLICE) inhibitory protein). As an important modulator of apoptosis, FLIP regulates life and death in various types of normal cells and tissues, such as lymphoid cells, and renders resistance to death receptor-mediated apoptosis in many types of tumor cells. Therefore, understanding the signals that control FLIP is vital to understanding and controlling diseases such as cancer. Here, we discuss the mechanisms that regulate FLIP activation by tumor necrosis factor (TNF), and their functional significance in regulating apoptotic processes.

Authors

Stuart A. Rushworth

University of East Anglia; Norwich, UK

Alison Taylor

University of East Anglia; Norwich, UK

Susana Langa

University of East Anglia; Norwich, UK

David J. MacEwan

University of East Anglia; Norwich, UK

Purchase article for $19

Subscribe to this journal for $129/year