Letter to the Editor

Multiple Kinases and System Robustness: A Link Between Cdc37 and Genome Integrity

Volume 6, Issue 24   December 15, 2007
Pages 3145 - 3147
http://dx.doi.org/10.4161/cc.6.24.5147
Authors: Avrom J. Caplan, Avi Ma'ayan and Ian M. Willis

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Abstract:
We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

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