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Letter to the Editor

Multiple Kinases and System Robustness: A Link Between Cdc37 and Genome Integrity

Avrom J. Caplan, Avi Ma'ayan and Ian M. Willis

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We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Authors

Avrom J. Caplan

Mount Sinai School of Medicine; New York, NY

Avi Ma'ayan

Mount Sinai School of Medicine; New York, NY

Ian M. Willis

Albert Einstein College of Medicine; New York, NY

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.