Paradoxes of Aging
Volume 6, Issue 24
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December 15, 2007
Pages 2997 - 3003http://dx.doi.org/10.4161/cc.6.24.5124
Authors: Mikhail V. Blagosklonny View affiliations
Insightful articles by Kirkwood and other outstanding scientists reveal paradoxes of aging. The source of paradoxes is an assumption that aging is caused by random accumulation of molecular damage. Here I demonstrate that a concept of TOR-driven program-like aging almost automatically resolves eleven paradoxes of aging. This article discusses why the accumulation of molecular damage does not limit life span, why calorie restriction and inhibition of protein synthesis extend life span, why non-existing program for aging is nevertheless robust, why a key gene for aging cannot be found by knocking it out, why low insulin is associated with good health but low insulin response with bad health, why aging is not a disease but can be treated as a disease, why healthy aging is slow aging, and how do we know that calorie restriction actually slows aging in humans.