Sign up for Table of Contents Alerts.

Email this page

Print this page

Conceptual Review

Paradoxes of Aging

Mikhail V. Blagosklonny

Purchase article for $19

Subscribe to this journal for $129/year

Insightful articles by Kirkwood and other outstanding scientists reveal paradoxes of aging. The source of paradoxes is an assumption that aging is caused by random accumulation of molecular damage. Here I demonstrate that a concept of TOR-driven program-like aging almost automatically resolves eleven paradoxes of aging. This article discusses why the accumulation of molecular damage does not limit life span, why calorie restriction and inhibition of protein synthesis extend life span, why non-existing ‘program’ for aging is nevertheless robust, why a key gene for aging cannot be found by knocking it out, why low insulin is associated with good health but low insulin response with bad health, why aging is not a disease but can be treated as a disease, why ‘healthy’ aging is slow aging, and how do we know that calorie restriction actually slows aging in humans.

Authors

Mikhail V. Blagosklonny

Ordway Research Institute; Albany, NY

Purchase article for $19

Subscribe to this journal for $129/year