Sign up for Table of Contents Alerts.

Email this page

Print this page

Extra Views

Multiple Mechanisms for p27^Kip1 Translocation and Degradation

Etsuo Susaki and Keiichi I. Nakayama

Purchase article for $19

Subscribe to this journal for $129/year

The nuclear export and rapid degradation of p27^Kip1 at the G₀–G₁ transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G₀–G₁ transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G1 progression.

Authors

Etsuo Susaki

Kyushu University; Fukuoka, Japan

Keiichi I. Nakayama

Kyushu University; Fukuoka, Japan

Purchase article for $19

Subscribe to this journal for $129/year