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Interweaving the Cell Cycle Machinery with Cell Differentiation

Jeffrey P. Miller, Nancy Yeh, Anxo Vidal and Andrew Koff

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A comprehensive understanding of the mechanisms coupling cell cycle exit and differentiation is important for both cancer biology and tissue development. Cancer cells can arise from either stem/progenitor cells that fail to exit the cell cycle and differentiate, or from de-differentiated cells that have re-entered the cell cycle. Much of our current understanding of this coupling is based on observations made in transformed cell lines. These studies have shown that enforcing proliferation prevents differentiation and inducing growth arrest leads to differentiation; thus, one widely-held view is that changes in cell cycle regulators simply induces cell cycle exit, a pre-requisite for differentiation. However, recent evidence indicates that cell cycle regulators can affect differentiation in other ways as well. They can have a role establishing the new transcriptional program that accompanies differentiation—in its most radical form, the molecular mechanism of arrest might even be an integral component of the differentiation program. Additionally, the regulators or mechanisms that prevent the re-entry of cells into the proliferative cycle may not be those that induce exit from the cell cycle. Our goal in this perspective is to highlight examples from our laboratory that provided a broader understanding of the types of roles that cell cycle regulators play during differentiation, beginning with the phenotypes observed in mice.

Authors

Jeffrey P. Miller

Memorial Sloan-Kettering Cancer Center; New York, NY

Nancy Yeh

Memorial Sloan-Kettering Cancer Center; New York, NY

Anxo Vidal

Memorial Sloan-Kettering Cancer Center; New York, NY

Andrew Koff

Memorial Sloan-Kettering Cancer Center; New York, NYa-koff@ski.mskcc.org

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.