Adult Stem Cell Specification by Wnt Signaling in Muscle Regeneration
Volume 2, Issue 5
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Pages 417 - 418http://dx.doi.org/10.4161/cc.2.5.498
Authors: Patrick Seale, Anna Polesskaya and Michael A. Rudnicki View affiliations
Recently, we describe a biological role for endogenous CD45+ stem cells in maintaining muscle integrity by participating in regeneration. Our experiments further establish that Wnt-signaling is the mechanism by which resident CD45+ adult stem cells are induced to undergo myogenic specification during muscle regeneration. Importantly, our study suggests that targeting the Wnt-pathway represents a promising therapeutic approach for the treatment of neuromuscular degenerative diseases.