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Let-7 Prevents Early Cancer Progression by Suppressing Expression of the Embryonic Gene HMGA2
Sun-Mi Park, Scott Shell, Amir Reza Radjabi, Robert Schickel, Christine Feig, Ben Boyerinas, Daniela M. Dinulescu, Ernst Lengyel and Marcus E. Peter
volume 6 | issue 21
1 November 2007Pages: 2585 - 2590
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The microRNA let-7 regulates late embryonic development by suppressing expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS. Its expression inversely correlates with the expression of let-7 in the NCI60 cells lines, and the expression of RAS does not change when amounts of let-7 that efficiently silence expression of HMGA2 are introduced into tumor cells. We did not find a difference in the expression of HMGA2 between primary ovarian cancer samples and matching metastases, suggesting that the expression of HMGA2 represents an early event during cancer progression. The late repression of HMGA2 by let-7 during embryonic development, and the early reexpression of HMGA2 during cancer development, is in line with the hypothesis that cancer development represents a case of reverse embryogenesis.
Authors
Sun-Mi Park
University of Chicago; Chicago, IL
Scott Shell
University of Chicago; Chicago, IL
Amir Reza Radjabi
University of Chicago; Chicago, IL
Robert Schickel
University of Chicago; Chicago, IL
Christine Feig
University of Chicago; Chicago, IL
Ben Boyerinas
University of Chicago; Chicago, IL
Daniela M. Dinulescu
Harvard Medical School; Brigham and Women's Hospital; Boston, MA
Ernst Lengyel
University of Chicago; Chicago, IL
Marcus E. Peter
University of Chicago; Chicago, IL