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Review

Resveratrol: From Basic Science to the Clinic

Valeria Cucciolla, Adriana Borriello, Adriana Oliva, Patrizia Galletti, Vincenzo Zappia and Fulvio Della Ragione

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Plants produce an extraordinary array of low-molecular-mass natural products endowed with biological activity. Among these molecules, resveratrol (3,5,4’-trihydroxystilbene) has been identified as an inhibitor of carcinogenesis with a pleiotropic mode of action. Extensive Literature on its anticancer activity, performed in cellular models, suggests a potential antiproliferative and apoptogenic use of the stilbene. Similarly, studies on implanted cancers and chemical-induced tumors confirm a potential chemotherapeutical interest of the compound. Moreover, recent intriguing studies have demonstrated, in mice, that the negative effects (insulin resistance and hyperglycemia) of a high-fat diet might be prevented by resveratrol treatment. Despite these promising observations, only few clinical trials have been performed on the compound due to the scarce interest of pharmaceutical industry. We suggest that resveratrol might be considered an interesting compound in association with more specific target-oriented drugs.

Authors

Valeria Cucciolla

Second University of Naples, Naples, Italy

Adriana Borriello

Second University of Naples, Naples, Italy

Adriana Oliva

Second University of Naples, Naples, Italy

Patrizia Galletti

Second University of Naples; Naples, Italy

Vincenzo Zappia

Second University of Naples, Naples, Italy

Fulvio Della Ragione

Second University of Naples, Naples, Italy

Purchase article for $19

Subscribe to this journal for $129/year