Chromosomal Instability in Cancer: Causality and Interdependence
Volume 6, Issue 19
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October 1, 2007
Pages 2341 - 2343http://dx.doi.org/10.4161/cc.6.19.4753
Authors: Ashok R. Venkitaraman View affiliations
Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.