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Chromosomal Instability in Cancer: Causality and Interdependence

Ashok R. Venkitaraman

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Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.

Authors

Ashok R. Venkitaraman

University of Cambridge; Cambridge UK

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Subscribe to this journal for $129/year