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Targeting the Hedgehog Pathway to Mitigate Treatment Resistance

Yu-Jen Chen, Jennifer Sims-Mourtada, Julie Izzo and K.S. Clifford Chao

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‘Hedgehog’ (HH) molecules are secretory signaling proteins that were first discovered in Drosophila. Three HH homologues have been identified in humans including Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH). During embryonic development, the Hedgehog (HH) signaling pathway is critical, and it regulates both proliferation and differentiation of various types of stem cells.1 This article provides a brief overview of HH signaling, summarizes the correlation between HH signaling and treatment resistance of cancer cells, and discusses the recent advances in targeting this signaling cascade to overcome treatment resistance with supporting experimental results.

Authors

Yu-Jen Chen

The University of Texas MD Anderson Cancer Center; Houston, Texas

Jennifer Sims-Mourtada

The University of Texas MD Anderson Cancer Center; Houston, Texas

Julie Izzo

Mackay Memorial Hospital; Taipei, Taiwan

K.S. Clifford Chao

The University of Texas MD Anderson Cancer Center; Houston, Texas

Purchase article for $19

Subscribe to this journal for $129/year