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Perspectives

The Role of Ubiquitination in the Direct Mitochondrial Death Program of p53

Natasha D. Marchenko and Ute M. Moll

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p53 ubiquitination at C-terminal lysines by MDM2 and other E3 ligases had been considered a straightforward negative regulation of p53 with only one function, that is marking the protein for proteasomal degradation. In this review, we will focus on the recently uncovered activating role of ubiquitination in the transcription-independent direct mitochondrial death program of p53.

Authors

Natasha D. Marchenko

State University of New York at Stony Brook; Stony Brook, NY USA

Ute M. Moll

Stony Brook University; Stony Brook, NY

Purchase article for $19

Subscribe to this journal for $129/year