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Review

MiT Transcription Factor Associated Malignancies in Man

Ian J. Davis and David E. Fisher

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The discovery of recurrent genetic abnormalities in cancer cells has often led to the identification of novel oncogenic genes and gene families. The nature of these alterations may also offer insights into the mechanisms by which these genes mediate their oncogenic role. Amplification, translocation, deletion and point mutation are common mechanisms that result in gain- or loss-of-function of cancer associated genes. Several studies have recently demonstrated multiple genetic strategies that ultimately converge to dysregulate members of the MiT transcription factor family in cancer. The shared dependence on aberrant MiT activity thus defines an expanding family of human solid tumors.

Authors

Ian J. Davis

University of North Carolina at Chapel Hill; Chapel Hill, North Carolina

David E. Fisher

Dana-Farber Cancer Institute; Boston, Massachusetts

Purchase article for $19

Subscribe to this journal for $129/year