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Aberrant Cytoplasmic Localization of N-CoR in Colorectal Tumors

Vaness Fernández-Majada, Jaume Pujadas, Felip Vilardell, Gabriel Capella, Marty W. Mayo, Anna Bigas and Lluis Espinosa

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We have previously shown that IKKs are aberrantly activated in colon cancer cells leading to SMRT phosphorylation and its release from the chromatin. We now show that IKKα phosphorylates the homologous N-CoR corepressor in serines 2345 and 2348 creating a functional 14-3-3 binding domain (RKpS2348KSP). Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors.

Authors

Vaness Fernández-Majada

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Jaume Pujadas

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Felip Vilardell

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Gabriel Capella

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Marty W. Mayo

The University of Virginia; Charlottesville, Virginia

Anna Bigas

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Lluis Espinosa

Institut d’Investigacio Biomèdica de Bellvitge, IDIBELL; Barcelona, Spain

Purchase article for $19

Subscribe to this journal for $129/year