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Regulation of microRNA Expression: the Hypoxic Component

Ritu Kulshreshtha, Manuela Ferracin, Massimo Negrini, George A. Calin, Ramana V. Davuluri and Mircea Ivan

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microRNAs are involved in a wide variety of normal and pathological cellular processes, including tumorigenic transformation. Despite significant progress made towards understanding their mechanisms of action, much less is known about the regulation of expression of specific microRNAs. Recent reports have established a link between hypoxia, a key feature of the tumor microenvironment, and a group of microRNAs. Select members of this group seem to affect apoptotic signaling in a hypoxic environment and are also predicted to target genes of critical importance for tumor biology. Interestingly, most hypoxia-induced microRNAs are also overexpressed in human cancers, suggesting a role in tumorigenesis. We hereby discuss the known and predicted regulators of microRNA expression and approaches for expanding this fledgling research area.

Authors

Ritu Kulshreshtha

Tufts - New England Medical Center, Boston, Massachusetts

Manuela Ferracin

University of Ferrara, Ferrara, Italy

Massimo Negrini

University of Ferrara, Ferrara, Italy

George A. Calin

University of Texas MD Anderson Cancer Center, Houston, Texas

Ramana V. Davuluri

Comprehensive Cancer Center, Ohio State University, Columbus, Ohio

Mircea Ivan

Tufts - New England Medical Center, Boston, Massachusetts

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.