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Perspectives

Notch Function in Myogenesis

Elena Vasyutina, Diana C. Lenhard and Carmen Birchmeier

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Notch genes encode cell surface proteins, which are evolutionary conserved and found in invertebrates like Drosophila melanogaster as well as in all vertebrate species. The transcription factor RBP-J (Rbpsuh) is a primary nuclear mediator of Notch signals. Signals provided by Notch receptors control cell fate decisions, patterning, and they also affect proliferation or the maintenance of progenitor cells. In these Perspectives we highlight the recent findings on the role of Notch/RBP-J signaling in the maintenance of muscle progenitor cells during embryogenesis and in the generation of satellite cells in fetal development.

Authors

Elena Vasyutina

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

Diana C. Lenhard

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

Carmen Birchmeier

Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.