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Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR
Kotb Abdelmohsen, Ashish Lal, Hyeon Ho Kim and Myriam Gorospe
volume 6 | issue 11
1 June 2007Pages: 1288 - 1292
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The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expression of multiple target mRNAs. HuR was previously shown to bind to the mRNA encoding the apoptosome inhibitor prothymosin α (ProTα) and enhanced its translation and cytoplasmic abundance. More recently, HuR was shown to increase the stability of a target mRNA encoding the pro-survival deacetylase SIRT1. The discovery that HuR likewise binds to and promotes the expression of mRNAs encoding Bcl-2 and Mcl-1, two major anti-apoptotic effectors, strongly supports HuR’s role as a key upstream coordinator of a constitutive pro-survival program.
Authors
Kotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, National Institute on Aging-IRP, National Institutes of Health; Baltimore, Maryland USA
Ashish Lal
Laboratory of Cellular and Molecular Biology, National Institute on Aging-IRP, National Institutes of Health; Baltimore, Maryland USA
Hyeon Ho Kim
Laboratory of Cellular and Molecular Biology, National Institute on Aging-IRP, National Institutes of Health; Baltimore, Maryland USA
Myriam Gorospe
Laboratory of Cellular and Molecular Biology, National Institute on Aging-IRP, National Institutes of Health; Baltimore, Maryland USA