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Perspectives

Circadian Clock and Breast Cancer: A Molecular Link

Saurabh Sahar and Paolo Sassone-Corsi

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The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms. Consequently, abnormal functioning of the clock results in severe dysfunctions and pathologies. Although epidemiological studies show a clear correlation between disruption of circadian rhythms and incidence of breast cancer, a molecular interpretation of how clock-related mechanisms may link to tumor development remains elusive. Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.

Authors

Saurabh Sahar

Department of Pharmacology, School of Medicine, University of California; Irvine, California USA

Paolo Sassone-Corsi

University of California at Irvine School of Medicine; Irvine, California

Purchase article for $19

Subscribe to this journal for $129/year