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Perspectives
The Role of Angiopoietin 2 in Hyperoxia-Inuduced Acute Lung Injury
Vineet Bhandari and Jack A. Elias
volume 6 | issue 9
2 May 2007Pages: 1049 - 1052
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Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.
Authors
Vineet Bhandari
Yale University School of Medicine, New Haven, Connecticut
Jack A. Elias
Yale University School of Medicine, New Haven, Connecticut
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.