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The Molecular Biology of Mammalian SIRT Proteins: SIRT2 Functions on Cell Cycle Regulation
Toshiaki Inoue, Masaharu Hiratsuka, Mitsuhiko Osaki and Mitsuo Oshimura
volume 6 | issue 9
2 May 2007Pages: 1011 - 1018
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Sir2, an NAD+-dependent protein deacetylase, extends the lifespan in diverse species from yeast to flies. Mammals have 7 homologues of Sir2, SIRT1-7, which affect aging and metabolism and which are potential targets for pharmacologic intervention. We identified SIRT2, which preferentially deacetylates tubulin and histone H4, as a down-regulated protein in gliomas due to its epigenetic aberration. We herein discuss the role of SIRT2 in the mitotic checkpoint function and show that it may be as a potential target of anti-cancer drugs.
Authors
Toshiaki Inoue
Tottori University, Tottori, Japan
Masaharu Hiratsuka
Tottori University, Tottori, Japan
Mitsuhiko Osaki
Tottori University, Tottori, Japan
Mitsuo Oshimura
Tottori University, Tottori, Japan
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.