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Perspectives
Lineage-Specific Transcription Factors in Multipotent Hematopoietic Progenitors: A Little Bit Goes a Long Way
Stefania Bottardi, Alireza Fotouhi Ghiam, François Bergeron and Eric Milot
volume 6 | issue 9
2 May 2007Pages: 1035 - 1039
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Basal expression of lineage-specific transcription factors (TFs) in multipotent hematopoietic progenitor cells (HPCs) plays a pivotal role in normal hematopoiesis. Indeed, the interplay between lineage-specific TFs and chromatin modifying or remodeling complexes allows chromatin modifications at specific hematopoietic loci and promotes transcriptionally prone conformations. It is now well accepted that during hematopoiesis, the expression of various lineage-specific genes can be preceded by their potentiation i.e., by chromatin activation, in progenitor cells. Gene potentiation appears to counterbalance epigenetic silencing of lineage-specific genes in early progenitors, while maintaining an accessible chromatin conformation in the lineage pathway selected. Herein, we discuss the impact of lineage-specific TFs on gene potentiation and priming in normal hematopoiesis, and emphasize the complementary role of locus control region (LCR) or LCR-like structures and promoter regions in gene-specific potentiation events.
Authors
Stefania Bottardi
University of Montreal, Montreal, Quebec Canada
Alireza Fotouhi Ghiam
University of Montreal, Montreal, Quebec Canada
François Bergeron
University of Montreal, Montreal, Quebec Canada
Eric Milot
University of Montreal, Montreal, Quebec Canada
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.