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Perspectives

Macrophage Migration Inhibitory Factor Coordinates DNA Damage Response with the Proteasomal Control of the Cell Cycle

Alice Nemajerova, Ute M. Moll, Oleksi Petrenko and Günter Fingerle-Rowson

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Proper repair of DNA damage is critical for protecting genomic stability, cellular viability and suppression of tumorigenesis. Both p53-dependent and p53-independent pathways have evolved to coordinate the cellular response following DNA damage. In this review, we highlight the importance of the ubiquitously expressed protein macrophage migration inhibitory factor (MIF) for an appropriate response to DNA damage. We discuss the mechanisms by which MIF affects the activity of the ubiquitin-proteasome system, and how this impacts on the integrity of the genome and on cancer.

Authors

Alice Nemajerova

State University of New York at Stony Brook; Stony Brook, NY

Ute M. Moll

Stony Brook University; Stony Brook, NY

Oleksi Petrenko

State University of New York at Stony Brook; Stony Brook, NY

Günter Fingerle-Rowson

University Hospital Cologne, Cologne, Germany

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.