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The INO80 Chromatin Remodeling Complex Functions in Sister Chromatid Cohesion
Hideaki Ogiwara, Takemi Enomoto and Masayuki Seki
volume 6 | issue 9
2 May 2007Pages: 1090 - 1095
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Here we identify a defect in sister chromatid cohesion in the Saccharomyces serevisiae arp8 mutant, which impairs the chromatin remodeling activity of the INO80 complex, and we report the direct association of Ino80 with centromeres and cohesin-associated regions. In early S phase, Ino80 is recruited to replication forks along with Ctf18 and PCNA, both of which are involved in the establishment of sister chromatid cohesion. The arp8 mutation perturbs the association of Ctf18 and PCNA but not of cohesin with replication forks. We propose that the INO80 complex is required for the proper establishment of sister chromatid cohesion.
Authors
Hideaki Ogiwara
Tohoku University, Sendai, Japan
Takemi Enomoto
Tohoku University, Sendai, Japan
Masayuki Seki
Tohoku University, Sendai, Japan
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.