Telling Cells How to Die: Docetaxel Therapy in Cancer Cell Lines

Héctor Hernández-Vargas, José Palacios and Gema Moreno-Bueno

volume 6 | issue 7

1 April 2007
Pages: 780 - 783

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:

Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.

Taxanes (paclitaxel and docetaxel) are antimicrotubule agents used in the clinical practice for the treatment of solid tumors. The molecular mechanisms of taxane-dependent cytotoxicity are only partially known. In vitro, different modes of action have been established for paclitaxel according to its concentration. A similar phenomenon has been shown for other microtubule-stabilizing drugs, including docetaxel. Recently, we described two different forms of mitotic exit in breast cancer cell lines exposed to docetaxel. The causes and consequences of the dual mechanism of cytotoxicity of this agent are discussed here.

Authors

Héctor Hernández-Vargas

Spanish National Cancer Centre; Madrid, Spain

José Palacios

Servicio de Anatomía Patológica; Sevilla, Spain

Gema Moreno-Bueno

Instituto de Investigaciones Biomedicas Alberto Sols; Madrid, Spain

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: