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Perspectives
Exercising Restraints: Role of Chk1 in Regulating the Onset and Progression of Unperturbed Mitosis in Vertebrate Cells
George Zachos and David Gillespie
volume 6 | issue 7
1 April 2007Pages: 810 - 813
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In vertebrate cells Chk1 is essential for multiple checkpoint responses to acute DNA damage or replication blocks, however potential functions for Chk1 during unperturbed cell cycles have remained less well characterised. In the past few years a role for Chk1 in timing the onset of mitosis in the absence of exogenous perturbations via regulation of Cdc25 family phosphatases has been documented. Furthermore, a recent report shows that Chk1 is also required for the spindle checkpoint which protects against spontaneous chromosome mis-segregation during mitotic cell division. Specifically, Chk1 is required for proper regulation of the mitotic Aurora-B kinase which ensures that anaphase proceeds only once all kinetochores have achieved bipolar attachment to microtubules and are under tension.
Authors
George Zachos
Beatson Institute for Cancer Research; Glasgow UK
David Gillespie
Beatson Institute for Cancer Research; Glasgow UK
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.