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Perspectives
SUMO is Growing Senescent
Oliver Bischof and Anne Dejean
volume 6 | issue 6
15 March 2007Pages: 677 - 681
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Cellular senescence is an irreversible cell cycle arrest that curbs unrestrained, aberrant proliferation of mammalian cells and is now recognized as a prominent tumor suppressive mechanism. We have shown recently that the E3 SUMO ligase PIASy actively contributes to execution of the senescence program, thus, providing the first evidence for a direct role of SUMO modification in this process. Here, we discuss some of the implications for this novel connection and future directions to study in more detail the importance of the SUMO pathway in senescence and tumorigenesis.
Authors
Oliver Bischof
Unité d’Organisation Nucléaire et Oncogenèse/INSERM; Institut Pasteur; Paris, France
Anne Dejean
Unité d’Organisation Nucléaire et Oncogenèse/INSERM; Institut Pasteur; Paris, France
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.