Mig-6, Signal Transduction, Stress Response and Cancer

Yu-Wen Zhang and George F. Vande Woude

volume 6 | issue 5

1 March 2007
Pages: 507 - 513

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The mitogen-inducible gene-6 (Mig-6) is an immediate early response gene encoding a nonkinase scaffolding adaptor protein. Mig-6 gene expression can be rapidly and robustly induced under both normal and pathological scenarios by factors including hormones, growth factors, and stresses. However, the precise role of Mig-6 has virtually been a mystery until recently, when we and others discovered that Mig-6 may play important roles in regulating stress response, maintaining homeostasis in tissues like joints or cardiac muscle, and functioning as a tumor suppressor. The discovery that Mig-6 acts as a negative feedback inhibitor of EGF receptor signaling through a direct, physical interaction with the EGF receptor opens a door for understanding the mechanism underlying Mig-6 function. Yet how Mig-6 fine tunes or integrates signal transduction in many pathophysiological situations remains to be determined. Here we will highlight recent discoveries on the role of Mig-6 in stress response, tissue homeostasis, and cancer development; review the transcriptional regulation of Mig-6 expression; share insight into its mechanism in regulating signal transduction; and discuss the paradox of its action modes under different pathophysiological conditions.

Authors

Yu-Wen Zhang

Van Andel Research Institute, Grand Rapids, Michigan

George F. Vande Woude

Van Andel Research Institute, Grand Rapids, Michigan

We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link: