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Perspectives
Survivin’s Dual Role: An Export’s View
Shirley K. Knauer, Wolf Mann and Roland H. Stauber
volume 6 | issue 5
1 March 2007Pages: 518 - 521
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Survivin is proposed to function as a mitotic regulator and an apoptosis inhibitor during development and pathogenesis. As such, survivin has aroused keen interest in disparate areas of basic and translational research. Survivin acts as a subunit of the chromosomal passenger complex (CPC), composed of the mitotic kinase Aurora-B, Borealin 5 and INCENP, and is essential for proper chromosome segregation and cytokinesis. Our recent findings indicate that the nuclear export receptor Crm1 is critically involved in tethering the CPC to the centromere by interacting with a leucine-rich nuclear export signal (NES), evolutionary conserved in all mammalian survivin proteins. In addition, the survivin/Crm1 interaction 10 seems to be required for the cytoprotective activity of survivin, because export deficient survivin fails to protect tumor cells against cancer therapy-induced apoptosis. These findings appear of clinical relevance since preferential nuclear localization of survivin turned out to be a favorable prognostic factor in cancer patients. Besides emphasizing the functional significance of the Crm1/survivin interface, we suggest to exploit the pharmacogenetic 15 interference with survivin’s export as a novel strategy to antagonize survivin’s activity.
Authors
Shirley K. Knauer
University of Mainz, Mainz, Germany
Wolf Mann
University of Mainz, Mainz, Germany
Roland H. Stauber
University of Mainz, Mainz, Germany
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.