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Perspectives
Notch, Myc and Breast Cancer
Argiris Efstratiadis, Matthias Szabolcs and Apostolos Klinakis
volume 6 | issue 4
15 February 2007Pages: 421 - 432
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The involvement of Myc in the development of human breast cancer is known for quite some time, but an analogous role of Notch signaling is only now emerging from fragmented pieces of information. Recently, a Notch/Myc relationship in oncogenesis was revealed from a mouse model, in which mammary tumors are induced by the intracellular domain of Notch1 (N1IC). In fact, a combination of genetic and molecular data demonstrated that Myc is a direct transcriptional target of Notch1 participating as an indispensable downstream effector in N1IC-induced tumorigenic action. A medically-relevant correlative observation based on immunophenotyping was the co-expression of Notch1 and Myc in a significant fraction of human breast cancer specimens. A Notch1/Myc oncogenic association was also observed in T-cell acute lymphoblastic leukemia.
Authors
Argiris Efstratiadis
Columbia University Medical Center, New York, NY
Matthias Szabolcs
Columbia University Medical Center, New York, NY
Apostolos Klinakis
Columbia University Medical Center, New York, NY
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.