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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
p63 Transcriptional Regulation of Epithelial Integrity and Cancer
Barry Trink, Motonobu Osada, Edward Ratovitski and David Sidransky
volume 6 | issue 3
1 February 2007Pages: 240 - 245
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p63 plays a more complex role than initially thought in cancer and development. As a p53 homolog, p63 encodes transcription factors that primarily functions through regulation of downstream gene expression. However, p63 is also involved in RNA processing and activation of β-catenin signaling. A number of genes activated by TAp63 support the notion that p63 is involved in tight transcriptional control of epithelial differentiation, cell adhesion, and tumorigenesis via cell cycle arrest, apoptosis, and other cellualr functions. In addition, ΔNp63 isotypes retain a rather short transactivation domain and were found to transcriptionally regulate a specific set of downstream gene targets. We found that p63 is capable of activating gene expression through binding to specific cis-elements, RE1 and RE2, with the latter being more specific for p63 than for p53. Differences in p53 family members DNA binding may help to explain key differences in their function and biology.
Authors
Barry Trink
Johns Hopkins University School of Medicine; Baltimore, MD
Motonobu Osada
The Johns Hopkins University School of Medicine; Baltimore, MD USA
Edward Ratovitski
The Johns Hopkins University School of Medicine; Baltimore, MD USA
David Sidransky
The Johns Hopkins University School of Medicine; Baltimore, MD USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.