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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
p63, Cell Adhesion and Survival
Danielle K. Carroll, Joan S. Brugge and Laura D. Attardi
volume 6 | issue 3
1 February 2007Pages: 255 - 261
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The development of stratified epithelia and its derivatives is a complex process requiring a multifaceted transcriptional program. p63, the p53-related transcription factor, is fundamental to this process. However, the underlying mechanisms by which p63 exerts its influence on stratified epithelial development and integrity remain elusive. Recent work from our laboratories has demonstrated that p63 mediates its effects on stratified epithelial function at least in part via its ability to regulate multiple aspects of epithelial cellular adhesion and survival. The identification of cell-cell and cell-matrix adhesion subprograms downstream of p63 provides an initial understanding of p63’s role in epithelial development, integrity and homeostasis.
Authors
Danielle K. Carroll
Harvard Medical School; Boston, MA USA
Joan S. Brugge
Harvard Medical School; Boston, MA USA
Laura D. Attardi
University School of Medicine; Stanford, CA USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.