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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
To Die or Not to Die: Neurons and p63
Freda D. Miller and David R. Kaplan
volume 6 | issue 3
1 February 2007Pages: 312 - 317
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
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One of the fundamental questions in neurobiology is how mammalian neurons survive for an organism’s lifetime in the face of normal ongoing “wear and tear” that, in the case of neurons in the peripheral nervous system, even includes physical damage. Elucidating the mechanisms that control neuronal survival is of importance not only for our understanding of normal development of neuronal circuitry, but also to devise treatments for pathological situations such as traumatic injury, or neurodegenerative conditions. In this review, we will cover the emerging evidence that p63 plays an essential role in regulating neuronal life and death decisions in the nervous system working in concert with its two other family members, p53 and p73.
Authors
Freda D. Miller
University of Toronto; Toronto, Ontario, Canada
David R. Kaplan
University of Toronto; Toronto, Ontario, Canada
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.