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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
p63, Cellular Senescence and Tumor Development
Xuecui Guo and Alea A. Mills
volume 6 | issue 3
1 February 2007Pages: 305 - 311
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Deficiency of p63, a p53-related protein, causes severe defects in epithelial morphogenesis. Studies of p63 compromised mouse models reveal that p63 deficiency induces cellular senescence both in cultured cells and in vivo, through regulation p19Arf/p53 and p16Ink4a/Rb pathways. An extensive tumor study of p63-compromised mice demonstrated that p63 deficiency does not predispose to, but rather protects from, tumor development. These findings further implicate p63 as a negative regulator of the tumor suppressive mechanism of cellular senescence.
Authors
Xuecui Guo
Cold Spring Harbor Laboratory; Cold Spring Harbor, New York USA
Alea A. Mills
Cold Spring Harbor Laboratory; Cold Spring Harbor, New York USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.