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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
Conflicting Roles for p63 in Skin Development and Carcinogenesis
Maranke I. Koster, Daisy Dai and Dennis R. Roop
volume 6 | issue 3
1 February 2007Pages: 269 - 273
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Epidermal morphogenesis is a complex process that culminates in the formation of a barrier that protects the organism from environmental substances and dehydration. p63, a transcription factor, is essential for normal epidermal morphogenesis as demonstrated by the failure of mice lacking p63 expression to develop an epidermis. However, since two independently generated p63-/- mouse models displayed different phenotypes, the role of p63 in epidermal morphogenesis has remained controversial. Furthermore, the tumor susceptibility phenotypes of both p63-/- mouse models were strikingly different. In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions.
Authors
Maranke I. Koster
Baylor College of Medicine; Houston TX, USA
Daisy Dai
Baylor College of Medicine; Houston TX, USA
Dennis R. Roop
Baylor College of Medicine; Houston TX, USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.