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A New Connection between the Spindle Checkpoint, Asymmetric Cell Division and Cytokine Signaling
Charlie Mantel and Hal E. Broxmeyer
volume 6 | issue 2
15 January 2007Pages: 144 - 146
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It is apparent from recent experimental evidence that a more detailed understanding of cancer stem cells is an important, yet poorly explored, aspect of tumor biology. It is believed that greater understanding of cancer stem cells could enhance treatment strategies for this disease. Understanding molecular mechanisms of self-renewal and differentiation of normal stem cells, such as hematopoietic stem cells, is a vital part of this emerging field. We have recently reported a new link between an important cell cycle timer/regulator, MAD2, and the cytokine, stem cell factor, and it’s receptor. Here we comment on potential implications of these new findings for understanding stem cell self-renewal and present new data supporting our interpretations.
Authors
Charlie Mantel
Indiana University School of Medicine; Indianapolis, IN
Hal E. Broxmeyer
Indiana University School of Medicine; Indianapolis, IN
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.