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Spotlight on p63 (Guest Editors, Gerry Melino and Frank McKeon)
Control of Keratinocyte Proliferation and Differentiation by p63
Amy B. Truong and Paul A. Khavari
volume 6 | issue 3
1 February 2007Pages: 295 - 299
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The p53 family member p63 has been implicated in both the development and maintenance of stratified epithelial tissues, including the epidermis. Increasing data support p63 function in the regenerative capacity of basal keratinocytes by maintaining cell proliferation. Recent studies further suggest this regulation relies on inhibition of p53 activity. In addition, p63 appears to exert separate control over epidermal differentiation, which may involve control of such key signaling molecules as IKKα and Notch. While studies over the past decade have greatly expanded our knowledge of p63 function, much remains to be understood regarding how p63 regulates epidermal homeostasis. Future efforts to identify and validate direct p63 target genes as well as to understand the expression and function of individual p63 isoforms will be important to further define how p63 functions in the control of keratinocyte proliferation and differentiation.
Authors
Amy B. Truong
Stanford University School of Medicine; Stanford, CA USA
Paul A. Khavari
Stanford University School of Medicine; Stanford, CA USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.