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Perspectives
Controlling Gene Expression through RNA Regulons: The Role of the Eukaryotic Translation Initiation Factor eIF4E
Biljana Culjkovic, Ivan Topisirovic and Katherine L.B. Borden
volume 6 | issue 1
1 January 2007Pages: 65 - 69
This is an open-access article
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The eukaryotic translation initiation factor eIF4E is a potent oncogene.1 In fact, its overexpression in human cancer often correlates with poor prognosis.1, 2 Traditionally, eIF4E plays a role in translation initiation where it binds the 5’ m7G cap found on mRNAs.3 More recent studies indicate that a significant fraction of eIF4E (up to 68%) resides in the nucleus where it regulates the nuclear export of specific mRNAs. Additionally, eIF4E may play a role in mRNA sequestration and stability in cytoplasmic processing bodies (P-bodies).4, 5 Our recent studies suggest that eIF4E governs cell cycle progression and cellular proliferation by coordinately orchestrating the expression of several genes at the post-transcriptional level. Hence, eIF4E functions as a central node of an RNA regulon (described below), which plays an essential role in normal differentiation and development and is frequently dysregulated in cancer. Several cellular factors, such as the promyelocytic leukemia protein PML, modulate the function of this regulon by altering the activity of eIF4E. Here, the physiological implications of these observations are described and the clinical implications of directly targeting eIF4E, and the related regulon, are discussed.
Authors
Biljana Culjkovic
Institute for Research in Immunology & Cancer and Department of Pathology and Cell Biology; Université de Montréal; Montréal, Quebec Canada
Ivan Topisirovic
Institute for Research in Immunology & Cancer and Department of Pathology and Cell Biology; Université de Montréal; Montréal, Quebec Canada
Katherine L.B. Borden
Institute for Research in Immunology & Cancer and Department of Pathology and Cell Biology; Université de Montréal; Montréal, Quebec Canada
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.