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Perspectives
Tumor Suppressor Dosage Regulates Stem Cell Dynamics during Aging
Catherine Gatza, Lynette Moore, Melissa Dumble and Lawrence A. Donehower
volume 6 | issue 1
1 January 2007Pages: 52 - 55
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The ability of tissues to maintain homeostasis is dependent in part on the function of adult tissue stem cells, which have the capability to self-renew and differentiate into multiple lineages. It has been hypothesized that the ability of stem cells to maintain tissue homeostasis declines functionally with age and that this decline may account for many of the biological phenotypes associated with aging. Recently, tumor suppressors such as p53 have been implicated in both aging and the regulation of stem cell dynamics. Our recent findings suggest that p53 may impact hematopoietic stem cell (HSC) dynamics during mammalian aging.25 Utilizing mouse models of varying levels of p53 dosage, we have shown that alteration of p53 activity affects stem cell number, proliferation, and functionality with age. Several other recent studies have implicated other tumor suppressors in potential age-related regulation of HSC dynamics as well.30,37 These data support a model in which aging is caused in part by a decline in tissue stem cell regenerative function, regulated in part by tumor suppressors.
Authors
Catherine Gatza
Baylor College of Medicine; Houston TX, USA
Lynette Moore
Baylor College of Medicine; Houston TX, USA
Melissa Dumble
Baylor College of Medicine; Houston TX, USA
Lawrence A. Donehower
Baylor College of Medicine; Houston TX, USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.