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S6-Haploinsufficiency Activates the p53 Tumor Suppressor
Linda Panić, Jacques Montagne, Maja Cokarić and Siniša Volarević
volume 6 | issue 1
1 January 2007Pages: 20 - 24
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The capacity to detect and appropriately respond to many different stresses that interfere with functional homeostasis is essential for survival. Recent evidence suggests that the nucleolus, the site of ribosome biogenesis, plays a critical role in sensing and responding to both external and internal stresses. To understand these processes, we have recently used a genetically defined in vivo mouse model in which ribosome biogenesis could be manipulated during oogenesis and embryo development. In these mice ribosomal biosynthesis is impaired by a conditional deletion of one allele of the gene encoding 40S ribosomal protein S6. Embryos from these animals fail during gastrulation, apparently due to a p53-dependent checkpoint being triggered, rather than a deficit in translational capacity. These findings imply that molecular mechanisms have evolved during mammalian evolution to strongly guard against potential heterozygosity for ribosomal protein genes.
Authors
Linda Panić
University of Rijeka, Croatia
Jacques Montagne
Centre de Génétique Moléculaire, Gif-sur-Yvette Cedex, France
Maja Cokarić
University of Rijeka, Croatia
Siniša Volarević
University of Rijeka, Croatia
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.